Protein H, an Antiphagocytic Surface Protein in Streptococcus pyogenes

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Protein H, an antiphagocytic surface protein in Streptococcus pyogenes.

Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mu...

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Streptococcal M protein was studied to ascertain its effect on macrophage functions such as oxidative metabolism, phagocytosis, and microbicidal activity. No significant stimulating activity of M protein against macrophage functions such as H 20 2 or 0 2 releasing ability in response to phorbol myristate acetate triggering was noted. M protein did not enhance the macrophage-mediated host risist...

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Expression of two different antiphagocytic M proteins by Streptococcus pyogenes of the OF+ lineage.

All clinical isolates of Streptococcus pyogenes (group A streptococcus) share the ability to resist phagocytosis and grow in human blood. In many strains, this property is due to the expression of a single antiphagocytic M protein, while other strains express more than one M-like molecule, of which the role in phagocytosis resistance is unclear. In particular, all S. pyogenes strains of the OF+...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1999

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.67.4.1708-1714.1999